HCID 22644798, compound → HCID 10298452, compound

HRID 2084864Notes

Reaction equation

C(OC1C=CC(S(N(CC#CCN(CC)CC)C(C(C)C)C(OC)=O)(=O)=O)=CC=1)C#CC.Cl.[CH2:34]([O:38][C:39]1[CH:44]=[CH:43][C:42]([S:45]([N:48]([CH2:57][C:58]#[C:59][CH2:60][N:61]([CH2:64][CH3:65])[CH2:62][CH3:63])[CH:49]([CH:54]([CH3:56])[CH3:55])[C:50]([NH:52][OH:53])=[O:51])(=[O:47])=[O:46])=[CH:41][CH:40]=1)[C:35]#[C:36][CH3:37]>>[CH2:34]([O:38][C:39]1[CH:40]=[CH:41][C:42]([S:45]([N:48]([CH:49]([CH:54]([CH3:56])[CH3:55])[C:50]([NH:52][OH:53])=[O:51])[CH2:57][C:58]#[C:59][CH2:60][N:61]([CH2:64][CH3:65])[CH2:62][CH3:63])(=[O:46])=[O:47])=[CH:43][CH:44]=1)[C:35]#[C:36][CH3:37]

Participants

Reactant 2

HCID 22644798HCID 22644798, compound

HCID 22644806HCID 22644806, compound

Product 1

HCID 10298452HCID 10298452, compound

Procedure

Methyl 2-{{[4-(2-butynyloxy)phenyl]sulfonyl}[4-(diethylamino)-2-butynyl]amino}-3-methylbutanoate was converted into 2-{{[4-(2-butynyloxy)phenyl]sulfonyl}[4-(diethylamino)-2-butynyl]amino}-N-hydroxy-3-methylbutanamide hydrochloride, isolated as a brown foam, according to the procedures of Examples 11 and 9. Electrospray Mass Spec 464.5 (M+H)+.

Workup

customisolated as a brown foam

Sources & evidence

ORD record: ord-fb12093329c945059517a99b1b2baf34
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716833B2

Reaction notes

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