反应详情

To a stirred solution of methyl 1-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)cyclohexane carboxylate (4.3 g, 11.8 mmol) in methanol:THF (4:1, 100 ml) 10 N sodium hydroxide (15 ml) was added at room temperature. It was stirred for 16 hrs and evaporated to dryness in vacuo. The residue was dissolved in 100 mL water, pH adjusted to 7 with 5N hydrochloric, acid solution. It was extracted with chloroform/methanol (3:1), washed with water, dried and concentrated to give 1-({[4-(2-butynyloxy)phenyl]sulfonyl}amino)cyclohexane carboxylic acid. Yield 4.0 g (98%); White solid, mp. 112-4° C. Electrospray Mass Spec 349 (M−H)−.

1. customevaporated to dryness in vacuo
2. dissolutionThe residue was dissolved in 100 mL water
3. extractionIt was extracted with chloroform/methanol (3:1)
4. washwashed with water
5. customdried
6. concentrationconcentrated