HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-[{[4-(2-Butynyloxy)phenyl]sulfonyl)(methyl)amino]-2-(4-chlorophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-2-(4-chlorophenyl)acetate | HCID 22645093 | — |
| Product | 2-[{[4-(2-Butynyloxy)phenyl]sulfonyl)(methyl)amino]-2-(4-chlorophenyl)acetic acid | HCID 22644891 | — |
Reaction Steps
This ester was reacted with excess methanolic lithium hydroxide at room temperature, followed by evaporation of the methanol. The residue was dissolved in water and acidified with 2N hydrochloric acid to give 2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-2-(4-chlorophenyl)acetic acid as colorless crystals, mp 170-172° C., Electrospray Mass Spec 406.4 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716833B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-b1a1b48b9a9440c7b014437f374071d4 |
| Source note | uspto-grants-2004_04 |