4-Benzyloxy-2-butyn-1-ol → Methyl 4-[(4-{[(benzyloxy)-2-butynyl]oxy)phenyl}-sulfonyl]-2,2-dimethyl-3-thiomorpholine carboxylate

Participants

Reaction Steps

According to the procedure of Step 4 of Example 243, Mitsunobu coupling of 0.345 g (1.0 mmol) of 4-(4-hydroxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester and 0.211 g (1.2 mmol) of 4-(benzyloxy)-2-butyn-1-ol provided 3.211 g (42%) of methyl 4-[(4-{[4-(benzyloxy)-2-butynyl]oxy}phenyl)sulfonyl]-2,2-dimethyl-3-thiomorpholine carboxylate as a pale yellow oil. Electrospray Mass Spec: 504.2 (M+H)+.

Provenance & Evidence