HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenyl-2-propyn-1-ol → HCID 57134211, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenyl-2-propyn-1-ol | HCID 123115 | — |
| Reactant | 4-(4-Hydroxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester | HCID 22731931 | — |
| Product | HCID 57134211 | HCID 57134211 | 55.3% |
Reaction Steps
According to the procedure of Step 2 of Example 248, Mitsunobu coupling of 0.345 g (1.0 mmol) of 4-(4-hydroxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid methyl ester and 0.159 g (1.2 mmol) of 3-phenyl-2-propyn-1-ol provided 0.254 g (55%) of methyl(3S)-2,2-dimethyl-4-({4-[(3-phenyl-2-propynyl)oxy]phenyl}sulfonyl)-3-thiomorpholine carboxylate as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716833B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-95fb55b3557947be82a3d0c83782cfcd |
| Source note | uspto-grants-2004_04 |