Ethylenediaminetetraacetic Acid → Gadolinium ethylenediaminetetraacetate sodium salt

HRID 2084980Notes

Reaction equation

HRID 2084980 reaction equation
[Cl-].[Gd+3:2].[Cl-].[Cl-].[CH2:5]([N:16]([CH2:21][C:22]([OH:24])=[O:23])[CH2:17][C:18]([OH:20])=[O:19])[CH2:6][N:7]([CH2:12][C:13]([OH:15])=[O:14])[CH2:8][C:9]([OH:11])=[O:10].C1C(C(N)=O)=CN(C2OC(COP(OP(OCC3OC(N4C5N=CN=C(N)C=5N=C4)C(OP([O-])([O-])=O)C3O)([O-])=O)([O-])=O)C(O)C2O)C=C1.[Na+:73].[Na+].[Na+].[Na+]>O>[Na+:73].[CH2:6]([N:7]([CH2:12][C:13]([O-:15])=[O:14])[CH2:8][C:9]([O-:11])=[O:10])[CH2:5][N:16]([CH2:21][C:22]([O-:24])=[O:23])[CH2:17][C:18]([O-:20])=[O:19].[Gd+3:2]

Participants

5

Reactant 3

HCID 6049Ethylenediaminetetraacetic AcidHCID 449676Gadolinium(3+);trichloride2×HCID 12598259[2-adenin-9-yl-5-[[[[5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate

Product 1

HCID 88024918Gadolinium ethylenediaminetetraacetate sodium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Gadolinium chloride (10 mmol) was dissolved in water (5 ml). Ethylenediaminetetraacetic acid, tetrasodium salt hydrate (10 mmol) was dissolved in water (10 ml) and added portionwise to the gadolinium chloride solution. The solution became warm, and after ca. 15 minutes, a white precipitate was formed. The mixture was left for a further 2 hours. The precipitate was filtered off to give a white solid which was washed with water (2×5 ml) and dried in air to yield Gadolinium ethylenediaminetetraacetate sodium salt, Na[Gd(EDTA)]

Workup

  1. temperatureThe solution became warm
  2. customa white precipitate was formed
  3. waitThe mixture was left for a further 2 hours
  4. filtrationThe precipitate was filtered off
  5. customto give a white solid which
  6. washwas washed with water (2×5 ml)
  7. customdried in air

Sources & evidence

ORD record
ord-ed6181645bb944d5866d97224631f765
Source dataset
uspto-grants-2004_04
Patent number
US06717354B1

Reaction notes

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