Ammonia → HCID 10198546, compound

Participants

Reaction Steps

3-chloro-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione (1.0 g, 4 mmol) was suspended in a mixture of ethanol (20 mL) and aqueous 880 ammonia (5 mL) and the mixture heated to 80° C. whilst ammonia gas was bubbled through the mixture for 4 hours. The mixture was cooled and concentrated and the residue chromatographed on silica get using hexane-ethyl acetate (gradient from 1:1 v/v) as eluent to afford the title compound as a solid.

Provenance & Evidence