HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Paroxetine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Paroxetine | HCID 43815 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Paroxetine Hydrochloride | HCID 62878 | — |
Reaction Steps
Paroxetine Base, 5 kg, is dissolved in 34.1 kg of methanol and then 16.7 kg (1:1.1 molar ratio to paroxetine base) of 1N hydrochloric acid is added to the solution under stirring to yield paroxetine HCl solution in a co-solvent of methanol and water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720003B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-f10de229949c4272ad4a3a52d583bdfb |
| Source note | uspto-grants-2004_04 |