HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-[Di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 2-[Di(benzyloxy)phosphoryloxy]ethanol | HCID 15256395 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[Di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate | HCID 21306625 | 45% |
Reaction Steps
4-Nitrophenyl chloroformate (1.01 g; 5.04 mmol) was added at 0° C. under argon atmosphere to a solution of 2-[di (benzyloxy)phosphoryloxy]ethanol (1.62 g; 5.09 mmol) and triethylamine (0.7 ml; 5 mmol) in dichloromethane (20 ml). The mixture was stirred at ambient temperature for 30 minutes, evaporated and purified by flash chromatography, eluting with petroleum ether/ethyl acetate (40/60) to give 2-[di(benzyloxy)phosphoryloxy]ethyl 4-nitrophenyl carbonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720323B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-48e392926bb045b09f4283b8b6f8778e |
| Source note | uspto-grants-2004_04 |