HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3(-4-Acetylpiperazino)propyl 4-nitrophenyl carbonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 1-(4-(3-Hydroxypropyl)piperazin-1-yl)ethan-1-one | HCID 11446771 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3(-4-Acetylpiperazino)propyl 4-nitrophenyl carbonate | HCID 22595011 | — |
Reaction Steps
4-Nitrophenyl chloroformate (0.733 g; 3.63 mmol) was added to a solution of 3-(4-acetylpiperazin-1-yl)propanol [Synthesis (1997), 6, 643-648] (0.645 g; 3.46 mmol) and triethylamine (0.51 ml; 3.36 mmol) in dichloromethane (7 ml) under argon atmosphere at 0° C. The mixture was stirred at ambient temperature for 1 hour, evaporated to dryness and purified by flash chromatography, eluting with dichloromethane/ethanol (95/5) to give 3(-4-acetylpiperazino)propyl 4-nitrophenyl carbonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720323B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-223bd66667b242b9b35d908798cba0b6 |
| Source note | uspto-grants-2004_04 |