Ethyl (morpholin-4-ylcarbonothioyl)carbamate → {[1-(4-Cyano-1-propyl-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butylimino]-morpholin-4-yl-methyl}-carbamic acid ethyl ester

HRID 2085034Notes

Reaction equation

HRID 2085034 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[NH:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=S)[CH3:2].Cl.Cl.[C:17]([C:19]1([NH:28][C:29](=[O:37])[CH:30]([NH2:36])[CH2:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH3:27])[CH2:21][CH2:20]1)#[N:18]>>[CH2:1]([O:3][C:4](=[O:14])[NH:5][C:6](=[N:36][CH:30]([C:29](=[O:37])[NH:28][C:19]1([C:17]#[N:18])[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH3:27])[CH2:21][CH2:20]1)[CH2:31][C:32]([CH3:34])([CH3:35])[CH3:33])[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)[CH3:2]

Participants

3

Reactant 2

HCID 2824559Ethyl (morpholin-4-ylcarbonothioyl)carbamateHCID 865852012-Amino-4,4-dimethyl-pentanoic acid(4-cyano-1-propyl-piperidin-4-yl)amide bis hydrochloride salt

Product 1

HCID 22091417{[1-(4-Cyano-1-propyl-piperidin-4-ylcarbamoyl)-3,3-dimethyl-butylimino]-morpholin-4-yl-methyl}-carbamic acid ethyl ester

Procedure

The title compound was prepared starting from (morpholine-4-carbothioyl)-carbamic acid ethyl ester and 2-amino-4,4-dimethyl-pentanoic acid (4-cyano-1-propyl-piperidin-4-yl)amide bis hydrochloride salt according to the procedure from Example 5. MS, m/z 460=M+1.

Sources & evidence

ORD record
ord-a49d59573c7544cdbde8bcb5e3259073
Source dataset
uspto-grants-2004_04
Patent number
US06720319B2

Reaction notes

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