Ethyl (morpholin-4-ylcarbonothioyl)carbamate → HCID 178473535, compound

HRID 2085035Notes

Reaction equation

HRID 2085035 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[NH:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=S)[CH3:2].Cl.Cl.[NH2:17][CH:18]([CH2:34][CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:19]([NH:21][C:22]1([C:32]#[N:33])[CH2:26][CH2:25][N:24]([CH:27]([CH2:30][CH3:31])[CH2:28][CH3:29])[CH2:23]1)=[O:20]>>[CH2:1]([O:3][C:4](=[O:14])[N:5]=[C:6]([NH:17][CH:18]([C:19](=[O:20])[NH:21][C:22]1([C:32]#[N:33])[CH2:26][CH2:25][N:24]([CH:27]([CH2:28][CH3:29])[CH2:30][CH3:31])[CH2:23]1)[CH2:34][CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)[CH3:2]

Participants

3

Reactant 2

HCID 2824559Ethyl (morpholin-4-ylcarbonothioyl)carbamateHCID 865852022-amino-N-[3-cyano-1-(1-ethyl-propyl)-pyrrolidin-3-yl]-3-cyclohexyl-propionamide bis hydrochloride salt

Product 1

HCID 178473535HCID 178473535, compound

Procedure

The title compound was prepared starting from (morpholine-4-carbothioyl)-carbamic acid ethyl ester and 2-amino-N-[3-cyano-1-(1-ethyl-propyl)-pyrrolidin-3-yl]-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 5, step b. MS, m/z 519=M+1.

Sources & evidence

ORD record
ord-e1c8b49d97424b1c85c98b175f4dfbc9
Source dataset
uspto-grants-2004_04
Patent number
US06720319B2

Reaction notes

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