HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N-(-4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt → HCID 178480339, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N-(-4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt | HCID 22566339 | — |
| Reactant | 3-Imino-2,3-dihydroisoindol-1-one | HCID 135742374 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178480339 | HCID 178480339 | — |
Reaction Steps
The title compound was prepared starting from 3-imino-2,3-dihydro-isoindol-1-one and 2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 10, except that refluxing THF was used as the solvent. The compound was further purified by HPLC using a 20×250 mm C18 reverse phase column with the method being 20% acetonitrile in water to acetonitrile. MS, m/z 422.5=M+1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720319B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-609b4b1ba3064d82bae5aeb72b895572 |
| Source note | uspto-grants-2004_04 |