2-amino-N-(-4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt → HCID 178480340, compound

HRID 2085044Notes

Reaction equation

HRID 2085044 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[C:7](=[O:12])[NH:6][C:5]2=[NH:13].Cl.Cl.N[CH:17]([CH2:30][CH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1)[C:18]([NH:20][C:21]1([C:28]#[N:29])[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]1)=[O:19]>>[C:28]([C:21]1([NH:20][C:18](=[O:19])[CH:17]([NH:13][C:5]2[C:4]3[C:8](=[CH:9][C:10]([F:11])=[C:2]([F:1])[CH:3]=3)[C:7](=[O:12])[N:6]=2)[CH2:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]1)#[N:29]

Participants

3

Reactant 2

HCID 225663392-amino-N-(-4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride saltHCID 1404324425,6-Difluoro-3-iminoisoindol-1-one

Product 1

HCID 178480340HCID 178480340, compound

Procedure

The title compound was prepared from 5,6-difluoro-2,3-dihydro-3-imino-1H-isoindol-1-one and 2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 15. MS, m/z 458.3=M+1.

Sources & evidence

ORD record
ord-4563bc0d79aa4524b261f66f7bdb77d8
Source dataset
uspto-grants-2004_04
Patent number
US06720319B2

Reaction notes

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