Ethyl 4-(m-methoxyphenyl)-3-phenyl-3-hydroxybutyrate → Ethyl 4-(m-methoxyphenyl)-3-phenylbutyrate

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Reaction Steps

A mixture of ethyl 4-(m-methoxyphenyl)-3-phenyl-3-hydroxybutyrate (4.39 g, 13.98 mmol), palladium/carbon (10%, 2.5 g) hydrochloric acid (1.2 mL) in acetic acid (150 mL) was subjected to hydrogenation (50 psi) for 24 hours. The catalyst was filtered, and the filtrate was concentrated to afford the desired product (1.89 g; 45% yield). 1H NMR was consistent with the desired product.

Provenance & Evidence