1,3-Dichloro-5-iodobenzene → HCID 60128507, compound

HRID 2085060Notes

Reaction equation

HRID 2085060 reaction equation
C1([C:7]#[C:8][C@@H:9]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[CH:19]=2)(=[O:17])=[O:16])[CH2:10][C:11]([OH:13])=[O:12])C=CC=CC=1.[Cl:36][C:37]1[CH:42]=[C:41](I)[CH:40]=[C:39]([Cl:44])[CH:38]=1>>[Cl:36][C:37]1[CH:42]=[C:41]([C:7]#[C:8][C@@H:9]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[CH:19]=2)(=[O:17])=[O:16])[CH2:10][C:11]([OH:13])=[O:12])[CH:40]=[C:39]([Cl:44])[CH:38]=1

Participants

3

Reactant 2

HCID 764241,3-Dichloro-5-iodobenzeneHCID 60128501HCID 60128501, compound

Product 1

HCID 60128507HCID 60128507, compound

Procedure

The procedure for the preparation of the product of EXAMPLE 18 was repeated using 1,3-dichloro-5-iodobenzene (Aldrich) in the place of iodobenzene to provide the title product. 1H (CD3OD): δ 7.88 (1H, t); 7.82 (1H, d); 7.50 (1H, d); 7.45 (1H, t); 7.43 (1H, s); 7.36 (1H, s); 7.10 (1H, d); 7.03 (1H, d); 6.91 (2H, s); 6.88 (1H, t); 4.68 (1H, t); 4.04 (2H, t); 3.40 (2H, t); 2.78 (2H, d); 1.87 (4H, m).

Sources & evidence

ORD record
ord-e67b85da05c843fb863f464a0eafc509
Source dataset
uspto-grants-2004_04
Patent number
US06720315B2

Reaction notes

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