2-Iodobenzene-1-sulfonamide → HCID 60128502, compound

HRID 2085061Notes

Reaction equation

[C:1]1([C:7]#[C:8][C@@H:9]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[CH:19]=2)(=[O:17])=[O:16])[CH2:10][C:11]([OH:13])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.IC1C=CC=CC=1[S:43]([NH2:46])(=[O:45])=[O:44]>>[NH2:46][S:43]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[C:7]#[C:8][C@@H:9]([NH:14][S:15]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH:19]=1)(=[O:17])=[O:16])[CH2:10][C:11]([OH:13])=[O:12])(=[O:45])=[O:44]

Participants

Reactant 2

HCID 28248922-Iodobenzene-1-sulfonamide

HCID 60128501HCID 60128501, compound

Product 1

HCID 60128502HCID 60128502, compound

Procedure

The procedure for the preparation of the product of EXAMPLE 18 was repeated using 2-iodobenzene-1-sulfonamide (Maybridge) in the place of iodobenzene to provide the title product. 1H (CD3OD): δ 7.88 (2H, m); 7.81 (1H, d); 7.52 (1H, d); 7.44 (4H, m); 7.11 (1H, d); 7.05 (2H, m); 6.87 (1H, t); 4.68 (1H, t); 4.01 (2H, m); 3.37 (2H, m); 2.84 (2H, m); 1.82 (4H, m).

Sources & evidence

ORD record: ord-8cb7acc7f2cf4ea8a1802fd0e7b4d8e5
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06720315B2

Reaction notes

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