L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1) → HCID 11464767, compound

HRID 2085064Notes

Reaction equation

HRID 2085064 reaction equation
FC(F)(F)C(O)=O.[N:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:21]=[C:22]([S:26](N[C@H](C#C)CC(O)=O)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1.Cl.C[O:39][C:40](=[O:48])[C@H:41]([CH2:43][C:44]([O:46]C)=[O:45])[NH2:42]>>[N:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:21]=[C:22]([S:26]([NH:42][C@H:41]([C:40]([OH:39])=[O:48])[CH2:43][C:44]([OH:46])=[O:45])(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 2734892L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1)HCID 86759416HCID 86759416, compound

Product 1

HCID 11464767HCID 11464767, compound

Procedure

The procedure for the preparation of the product of EXAMPLE 17 was repeated using L-aspartic acid dimethyl ester hydrochloride (Aldrich) in the place of ethyl (3S)-3-aminopent-4-ynoate hydrochloride to provide the title product. 1H (CD3OD): δ 7.88 (1H, t); 7.82 (1H, d); 7.42 (3H, m); 7.13 (1H, m); 7.05 (1H, d); 6.87 (1H, t); 4.20 (1H, t); 4.12 (2H, t); 3.44 (2H, t); 2.71 (2H, m); 1.93 (4H, m).

Sources & evidence

ORD record
ord-482207cdf949458bb93f1173557ab386
Source dataset
uspto-grants-2004_04
Patent number
US06720315B2

Reaction notes

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