反应详情

The crude cyclopropanated ester from above (1.09 g, 5.17 mmol) was dissolved in 30 mL MeOH and treated with 15 mL of 2 M aqueous NaOH solution. The mixture was stirred at room temperature for 2 h. It was then placed on a rotary evaporator to remove the MeOH. The remaining solution was diluted with water (30 mL), washed with ether (15 mL), then acidified with 5 M aqueous HCl solution. The product was extracted with ether (3×40 mL) and the combined organics were washed with brine and dried (MgSO4). After filtration, the solvents were removed in vacuo to afford 792 mg of 2-(3-chlorophenyl)-cyclopropanecarboxylic acid as a white solid (4.03 mmol, 78% yield).

1. customIt was then placed on a rotary evaporator
2. customto remove the MeOH
3. additionThe remaining solution was diluted with water (30 mL)
4. washwashed with ether (15 mL)
5. extractionThe product was extracted with ether (3×40 mL)
6. washthe combined organics were washed with brine
7. dry with materialdried (MgSO4)
8. filtrationAfter filtration
9. customthe solvents were removed in vacuo