HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine, hydrochloride → HCID 22729188, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 4-Methoxy cinnamic acid | HCID 13245 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Chloro-6-methoxy-1-benzothiophene-2-carboxylic acid | HCID 693153 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 22729188 | HCID 22729188 | — |
Reaction Steps
3.0 g of 3-chloro-6-methoxy-benzo(b)thiophene-2-carboxylic acid (7.0 g) synthesized from 4-methoxycinnamic acid (10.0 g) and thionyl chloride (15 ml) according to the method described in J. Med. Chem. 1992, 35, 958-965 was reacted with dimethylamine hydrochloride and triethylamine in THF to give the title compound (1.9 g) as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720320B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-7cee0e6c58cd4c70a0c43d6d021a0cff |
| Source note | uspto-grants-2004_04 |