Boron tribromide → 3-(7-Hydroxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole

HRID 2085142Notes

Reaction equation

C[O:2][C:3]1[C:8]2[O:9][C:10]([C:12]3[N:16]=[C:15]([CH3:17])[O:14][N:13]=3)=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[C:8]2[O:9][C:10]([C:12]3[N:16]=[C:15]([CH3:17])[O:14][N:13]=3)=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 227293143-(7-Methoxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole

Product 1

HCID 227290843-(7-Hydroxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazoleYield 94%

Procedure

By the reactions in the same manner as in Starting Material Synthesis Example 5 using 3-(7-methoxybenzo(b)furan-2-yl)-5-methyl-1,2,4-oxadiazole (1.7 g) and boron tribromide (6.5 ml), the title compound (1.5 g) was obtained as white crystals.

Sources & evidence

ORD record: ord-7f055f965aff4288849cec01acd79657
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06720320B2

Reaction notes

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