HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 22729266, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetohydrazide | HCID 14039 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-Methoxy-1-benzofuran-2-carboxylic acid | HCID 22728982 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22729266 | HCID 22729266 | 68.5% |
Reaction Steps
To a solution (700 ml) of 4-methoxybenzo(b)furan-2-carboxylic acid (43.4 g) in THF was added 1,1′-carbonylbis-1H-imidazole (CDI) (38.4 g) and the mixture was stirred at room temperature for 1 hr. Acetohydrazine (17.6 g) was added to this reaction mixture, and the mixture was stirred for 1 more hr. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration and dried to give the title compound (38.4 g) as pale-brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720320B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-cd7db74b0fcc48caa2d91ae072005262 |
| Source note | uspto-grants-2004_04 |