Boron tribromide → 2-(5-Methyl-1,3,4-oxadiazol-2-yl)benzofuran-4-ol

HRID 2085146Notes

Reaction equation

C[O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]3[O:13][C:14]([CH3:17])=[N:15][N:16]=3)[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]3[O:13][C:14]([CH3:17])=[N:15][N:16]=3)[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 22728930HCID 22728930, compound

Product 1

HCID 1357943242-(5-Methyl-1,3,4-oxadiazol-2-yl)benzofuran-4-olYield 54.1%

Procedure

By the reactions in the same manner as in Starting Material Synthesis Example 5 using 2-(4-methoxybenzo(b)furan-2-yl)-5-methyl-1,3,4-oxadiazole (6.5 g) and boron tribromide (27 ml), the title compound (3.3 g) was obtained as yellow crystals.

Sources & evidence

ORD record: ord-aac060d3c2394808b401775d75da4b0a
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06720320B2

Reaction notes

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