Hydrochloric Acid → 2-(2'-Hydroxystyryl)benzothiazole

HRID 2085168ノート

反応式

HRID 2085168 の反応式
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:10][C:11]1[S:12][CH:13]=[CH:14][N:15]=1.Cl.[OH-].[K+]>>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[CH:1]=[CH:10][C:11]1[S:12][C:13]2[CH:7]=[CH:8][CH:2]=[CH:1][C:14]=2[N:15]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 6998SalicylaldehydeHCID 14797Potassium HydroxideHCID 771292-Methylthiazole

生成物 1

HCID 1363860142-(2'-Hydroxystyryl)benzothiazole収率 39.5%

反応条件

温度
100 °C

実験手順

Salicylaldehyde (6.1 g) and 2-methylthiazole (7.5 g) were mixed and conc. hydrochloric acid (1.5 ml) was added thereto. The mixture was stirred with heating at 100° C. for 9 hr. The reaction mixture was cooled, and aqueous potassium hydroxide solution was added. The aqueous layer was washed with ether and made acidic with hydrochloric acid and extracted again with ethyl acetate. The organic solvent was dried and concentrated to give the title compound (2.5 g) as pale-yellow crystals, melting point 235-236° C.

後処理

  1. temperatureThe reaction mixture was cooled
  2. washThe aqueous layer was washed with ether
  3. extractionextracted again with ethyl acetate
  4. customThe organic solvent was dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-9d7606613c5042dea87c697bd46c9e03
出典データセット
uspto-grants-2004_04
特許番号
US06720320B2

反応ノート

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