Methanesulfonic Acid → HCID 22729310, Verbindung

HRID 2085175Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2085175
[CH3:1][O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]([NH:14][NH:15][C:16](=O)[CH3:17])=[S:13])[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.CS(O)(=O)=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]3[S:13][C:16]([CH3:17])=[N:15][N:14]=3)[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 6395Methanesulfonic AcidHCID 86585642HCID 86585642, Verbindung

Produkt 1

HCID 22729310HCID 22729310, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution (50 ml) of N′-(4-methoxybenzo(b)furan-2-ylthiocarbonyl)acetohydrazide (1.1 g) in toluene was added methanesulfonic acid (1.0 ml) and the mixture was stirred at 80° C. for 30 min. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate and aqueous potassium carbonate solution, followed by partitioning. After washing with water, the organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give the title compound (0.82 g) as yellow crystals.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. customby partitioning
  4. washAfter washing with water
  5. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6c014668e8204a2a9b413020a55474c3
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06720320B2

Notizen zur Reaktion

Wird geladen…