HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-propargyl-4-(methoxymethyloxy)benzo(b)thiophene-2-carboxamide → 4-Hydroxy-2-(5-methyloxazol-2-yl)benzo(b)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-propargyl-4-(methoxymethyloxy)benzo(b)thiophene-2-carboxamide | HCID 22729210 | — |
| Catalyst | Mercurous acetate | HCID 61181 | — |
| Product | 4-Hydroxy-2-(5-methyloxazol-2-yl)benzo(b)thiophene | HCID 135794311 | 47.8% |
Reaction Steps
By the reactions in the same manner as in Starting Material Synthesis Example 5 using N-propargyl-4-(methoxymethyloxy)benzo(b)thiophene-2-carboxamide (6.00 g) and mercury acetate (765 mg), the title compound (2.41 g) was obtained as yellow crystals, melting point 188-189° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720320B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-7483137ccbd84caea8b51dcb8a6c2d38 |
| Source note | uspto-grants-2004_04 |