(S)-(+)-Glycidyl-4-nitrobenzoate → HCID 87858827, compound

HRID 2085205Notes

Reaction equation

HRID 2085205 reaction equation
[OH:1][C:2]1[C:7]2[O:8][C:9]([C:11]3[O:12][C:13]([CH3:16])=[CH:14][N:15]=3)=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.S(C1C=CC([N+]([O-])=O)=CC=1)(O[CH2:21][C@H:22]1[O:24][CH2:23]1)(=O)=O>>[CH2:21]([O:1][C:2]1[C:7]2[O:8][C:9]([C:11]3[O:12][C:13]([CH3:16])=[CH:14][N:15]=3)=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1)[C@H:22]1[O:24][CH2:23]1

Participants

3

Reactant 2

HCID 10868995(S)-(+)-Glycidyl-4-nitrobenzoateHCID 22728960HCID 22728960, compound

Product 1

HCID 87858827HCID 87858827, compoundYield 79.6%

Procedure

By the reactions in the same manner as in Starting Material Synthesis Example 1 using 2-(7-hydroxybenzo(b)furan-2-yl)-5-methyloxazole (2.0 g) obtained in Starting Material Synthesis Example 65 and (S)-glycidyl nosylate (1.8 g), (S)-7-glycidyloxy-2-(5-methyloxazol-2-yl)benzo(b)furan (1.5 g) was obtained. Then, by the reactions in the same manner as in Example 1 using 4-(naphthalen-2-yl)piperidine (0.7 g), the title compound (0.26 g) was obtained, melting point 147-149° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-e04256d8d9864b23aee8c43b2884e184
Source dataset
uspto-grants-2004_04
Patent number
US06720320B2

Reaction notes

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