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Potassium Carbonate → (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-(2-Hydroxybenzylidene)dihydrofuran-2(3h)-one | HCID 229758 | — |
| 反応物 | (S)-(+)-Glycidyl-4-nitrobenzoate | HCID 10868995 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone | HCID 86585643 | 70.8% |
反応手順
To α-(2′-hydroxybenzylidene)-γ-butyrolactone (60 g) were added dimethylformamide (600 ml) and potassium carbonate (87 g) and (S)-glycidyl nosylate (82 g) was added. The reaction mixture was stirred for 2 days at room temperature. The reaction mixture was concentrated under reduced pressure and water was added. The mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained crystals were recrystallized from ethyl acetate to give the title compound (55 g), melting point 68-70° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06720320B2 |
| 出典データセット | uspto-grants-2004_04 |
| ORD ID | ord-ec95c0c212214a49a780d89fc39ea472 |
| 出典メモ | uspto-grants-2004_04 |