HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-Chloro-3-(trifluoromethyl)phenyl]piperidine → (S)-alpha-(2'-(3-(4-(4-chloro-3-trifluoromethylphenyl)piperidino)-2-hydroxypropyloxy) benzylidene)-gamma-butyrolactone Hydrochloride Monohydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-Chloro-3-(trifluoromethyl)phenyl]piperidine | HCID 16679317 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone | HCID 86585643 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-alpha-(2'-(3-(4-(4-chloro-3-trifluoromethylphenyl)piperidino)-2-hydroxypropyloxy) benzylidene)-gamma-butyrolactone Hydrochloride Monohydrate | HCID 69497791 | 52.6% |
Reaction Steps
The reaction was performed in same manner as in Example 307 using (S)-α-(2′-(2,3-epoxypropan-1-yloxy)benzylidene)-γ-butyrolactone (1.0 g) and 4-(4-chloro-3-trifluoromethylphenyl) -piperidine (0.8 g) in methanol (50 ml), and the obtained oil was treated with methanol/hydrochloric acid to give the title compound (0.45 g), melting point 172-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720320B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-bb8a465cf6f54fb88bbafd07fbb74d70 |
| Source note | uspto-grants-2004_04 |