HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Naphthalen-1-YL)piperidine → (S)-alpha-(2'-(2-hydroxy-3-(4-(naphthalen-1-yl)piperidino)-propyloxy) benzylidene)-gamma-butyrolactone p-toluenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Naphthalen-1-YL)piperidine | HCID 14819316 | — |
| Reactant | Ethyl acetate p-toluenesulfonic acid | HCID 22729081 | — |
| Reactant | (S)-alpha-(2'-(2,3-epoxypropan-1-yloxy)benzylidene)-gamma-butyrolactone | HCID 86585643 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-alpha-(2'-(2-hydroxy-3-(4-(naphthalen-1-yl)piperidino)-propyloxy) benzylidene)-gamma-butyrolactone p-toluenesulfonate | HCID 86585644 | — |
Reaction Steps
The reaction was performed in same manner as in Example 307 using (S)-α-(2′-(2,3-epoxypropan-1-yloxy)benzylidene)-γ-butyrolactone (5.8 g) and 4-(naphthalen-1-yl)piperidine (5.0 g) in methanol (100 ml) and the obtained oil was treated with ethyl acetate/p-toluenesulfonic acid to give the title compound (7.8 g), melting point 119-121° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720320B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-b799a105b2564ff7a49dbf27e30860d1 |
| Source note | uspto-grants-2004_04 |