2-Furoyl isothiocyanate → N-[(4-{2-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]ethyl}piperidin-1-yl)carbonothioyl]-2-furamide

HRID 2085316Notes

Reaction equation

HRID 2085316 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]=[C:9]=[S:10])=[O:7].[CH2:11]([O:13][CH2:14][C:15]1[N:16]([CH2:27][CH2:28][CH:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[C:17]2[C:22]([CH3:23])=[C:21]([CH3:24])[N:20]=[C:19]([NH2:25])[C:18]=2[N:26]=1)[CH3:12]>>[NH2:25][C:19]1[C:18]2[N:26]=[C:15]([CH2:14][O:13][CH2:11][CH3:12])[N:16]([CH2:27][CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:9]([NH:8][C:6]([C:2]4[O:1][CH:5]=[CH:4][CH:3]=4)=[O:7])=[S:10])[CH2:31][CH2:30]3)[C:17]=2[C:22]([CH3:23])=[C:21]([CH3:24])[N:20]=1

Participants

3

Reactant 2

HCID 27592432-Furoyl isothiocyanateHCID 129729622-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine

Product 1

HCID 22397368N-[(4-{2-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]ethyl}piperidin-1-yl)carbonothioyl]-2-furamide

Procedure

Using the method of Examples 54-65, 2-furoylisothiocyanate was reacted with 2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 485.2357.

Sources & evidence

ORD record
ord-8a1c5328d0444750a98d16f4e734a40e
Source dataset
uspto-grants-2004_04
Patent number
US06720334B2

Reaction notes

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