4-Morpholinecarbonyl chloride → n-[2-(4-Amino-2,6,7-trimethyl-1h-imidazo[4,5-c]pyridin-1-yl)ethyl]morpholin-4-ylcarboxamide

HRID 2085326Notes

Reaction equation

HRID 2085326 reaction equation
[N:1]1([C:7](Cl)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:10][CH2:11][CH2:12][N:13]1[C:21]2[C:20]([CH3:22])=[C:19]([CH3:23])[N:18]=[C:17]([NH2:24])[C:16]=2[N:15]=[C:14]1[CH3:25]>>[NH2:24][C:17]1[C:16]2[N:15]=[C:14]([CH3:25])[N:13]([CH2:12][CH2:11][NH:10][C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[C:21]=2[C:20]([CH3:22])=[C:19]([CH3:23])[N:18]=1

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 219738201-(2-aminoethyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Product 1

HCID 10172074n-[2-(4-Amino-2,6,7-trimethyl-1h-imidazo[4,5-c]pyridin-1-yl)ethyl]morpholin-4-ylcarboxamide

Procedure

Using the method of Examples 118-133, 4-morpholinecarbonyl chloride was reacted with 1-(2-aminoethyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 333.2025.

Sources & evidence

ORD record
ord-466151a447d8415ab9f9dfa53c0960d0
Source dataset
uspto-grants-2004_04
Patent number
US06720334B2

Reaction notes

Loading…