HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(4-Nitrophenyl)-1,2,3,6-tetrahydropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-methyl-N-[3-(4-piperidyl)phenyl]propanamide | HCID 16757255 | — |
| Reactant | tert-butyl 5,6-dihydro-4-(4-nitrophenyl)pyridine-1(2H)-carboxylate | HCID 22049016 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(4-Nitrophenyl)-1,2,3,6-tetrahydropyridine | HCID 22048783 | — |
Reaction Steps
4-(4-Nitrophenyl)-1,2,3,6-tetrahydropyridine was prepared by a similar procedure to that used for the preparation of 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide using HCl gas and tert-Butyl 4-(4-Nitrophenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate (130 mg) in dioxane (5.0 mL) at room temperature. The reaction mixture was concentrated in vacuo to give the crude product (69.8 mg) that used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720324B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-53831d3c900142c2b258c9cff2735c9e |
| Source note | uspto-grants-2004_04 |