Pyridine → HCID 22725169, compound

Participants

Reaction Steps

4-Nitrophenyl chloroformate (1.886 g, 9.38 mmol) was added to a solution of 6-(3,4,5-trifluorophenyl)-1,6-dihydro-2-methoxy-5-acetyl-4-methylpyrimidine (2.80 g, 9.38 mmol) and pyridine (10 mL) in CH2Cl2 (200 mL) at 0-5° C. and then the mixture was allowed to warm to room temperature. After 12 h, the solvent was evaporated and the residue was purified by flash chromatography (CH2Cl2/EtOAc, 9/1 to 20/3), giving the desired product as a white powder (4.0 g, 92%).

Provenance & Evidence