HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (R)-(+)-beta-Methylphenethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (2R)-2-phenylpropylamine malate | HCID 21356831 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-(+)-beta-Methylphenethylamine | HCID 1547949 | — |
Reaction Steps
To a stirred suspension of (2R)-2-phenylpropylamine malate (24.3 g, 0.0601 mol, prepared directly above) in CH2Cl2 (200 mL) was added 1.0 N NaOH dropwise at room temperature. The organic phase was isolated, extracted with brine (1×125 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to give (2R)-2-phenylpropylamine (19 g) as a clear, colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720357B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-f91eeee381cc4b66ad5c6a4503b88760 |
| Source note | uspto-grants-2004_04 |