Dimethylamine → (2R)-N1,N1,3-Trimethyl-1,2-butanediamine

HRID 2085467Notes

Reaction equation

HRID 2085467 reaction equation
C(OC([NH:8][C@@H:9]([C:13](O)=O)[CH:10]([CH3:12])[CH3:11])=O)(C)(C)C.[CH3:16][NH:17][CH3:18]>>[CH3:11][CH:10]([CH3:12])[C@@H:9]([NH2:8])[CH2:13][N:17]([CH3:18])[CH3:16]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 637605(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid

Product 1

HCID 28599423(2R)-N1,N1,3-Trimethyl-1,2-butanediamine

Procedure

The starting material (R)-3,N1,N1-trimethyl-butane-1,2-diamine was prepared in a route similar to that in Example A45 from N-tert-butoxycarbonyl D-valine and dimethylamine and used without further purification.

Workup

  1. customused without further purification

Sources & evidence

ORD record
ord-b45eaf474ae444d3b31251b16be56455
Source dataset
uspto-grants-2004_04
Patent number
US06720346B2

Reaction notes

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