1-Methyl-5-aminomethylimidazole → 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-N-(1-methylimidazol-5-yl-methyl)-benzamide

HRID 2085471노트

반응식

HRID 2085471 반응식
[NH2:1][C:2]1[N:3]=[C:4]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=2)[S:5][C:6]=1[C:7](=[O:16])[C:8]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=1[F:15].[CH3:27][N:28]1[C:32]([CH2:33][NH2:34])=[CH:31][N:30]=[CH:29]1>>[NH2:1][C:2]1[N:3]=[C:4]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:34][CH2:33][C:32]3[N:28]([CH3:27])[CH:29]=[N:30][CH:31]=3)=[O:24])=[CH:20][CH:19]=2)[S:5][C:6]=1[C:7](=[O:16])[C:8]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=1[F:15]

참가 물질

3

반응물 2

HCID 27954241-Methyl-5-aminomethylimidazoleHCID 112573524-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic Acid

생성물 1

HCID 227310724-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-N-(1-methylimidazol-5-yl-methyl)-benzamide

실험 절차

The title compound was prepared in a manner analogous to Step 3 of Method A, from 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid (3) and C-(3-methyl-3H-imidazol-4-yl)-methylamine. Purified via preparative HPLC.

후처리

  1. customPurified via preparative HPLC

출처 및 근거

ORD 기록
ord-f12047a4633d4e35bee684340720e9ae
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06720346B2

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