HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic Acid → 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-N-(1-methyl-azetidin-3-ylmethyl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic Acid | HCID 11257352 | — |
| Reactant | tert-Butyl 3-carbamoylazetidine-1-carboxylate | HCID 21307329 | — |
| Product | 4-[4-Amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-N-(1-methyl-azetidin-3-ylmethyl)-benzamide | HCID 21307276 | — |
Reaction Steps
The title compound was prepared from 3-carbamoyl-azetidine-1-carboxylic acid tert-butyl ester after 1) reduction in a manner similar to similar to Step 2 in Example A39 and 2) subsequent coupling with 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid (3) in a manner similar to Step 3 in Method A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720346B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-f599393720834a379ddd97fd356af7df |
| Source note | uspto-grants-2004_04 |