1-(aminomethyl)-N,N-dimethylcyclobutan-1-amine → 4-{[4-Amino-5-(2,6-difluorobenzoyl)-1,3-thiazol-2-yl]amino}-N-{[1-(dimethylamino)cyclobutyl]methyl}benzamide

Participants

Reaction Steps

The title compound was prepared in a manner similar to Step 3 in Method A; from coupling 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid (3) and 1-(aminomethyl)-N,N-dimethylcyclobutanamine (Yang et al., Eur. J. Med. Chem. 31, 231-239 (1996)) to afford a yellow amorphous powder in 61% yield.

Provenance & Evidence