2-Fluorotoluene → 2-Chloro-4-[1-(4-fluoro-3-methyl-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

HRID 208549Notes

Reaction equation

HRID 208549 reaction equation
[BH:16]([OH:17])[OH:18].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][c:10]2[n:11][c:12]([CH3:15])[nH:13][cH:14]2)[cH:7]1.[F:19][c:20]1[c:21]([CH3:26])[cH:22][cH:23][cH:24][cH:25]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][c:10]2[n:11][c:12]([CH3:15])[n:13](-[c:23]3[cH:22][c:21]([CH3:26])[c:20]([F:19])[cH:25][cH:24]3)[cH:14]2)[cH:7]1

Participants

4

Reactant 3

HCID 72412-FluorotolueneHCID 61668Boronic AcidHCID 178418879HCID 178418879, compound

Product 1

HCID 865953162-Chloro-4-[1-(4-fluoro-3-methyl-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

Sources & evidence

ORD record
ord-8e612c4cc45347c5afa8faa425e55445
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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