Acetophenone → 1-Phenylethanol, (R)-

Participants

Reaction Steps

Chiral hydrogenation of acetophenone was carried out (see formula (7) below). That is, a reaction was carried out in accordance with the procedures of Example 4 using the (S,SS)-ruthenium hydride complex (1.5 mg; 0.00125 mmol) synthesized in Example 2 and using acetophenone (150 mg; 1.25 mmol) as the substrate and 2-propanol (1.5 mL) as the solvent. However, the hydrogen pressure was set to 1 atmosphere, the reaction temperature was set to 25° C., and the reaction time was set to 12 hours. As a result, (R)-1-phenylethanol was obtained at a conversion rate of 99%, isolation yield of 95% (293 mg; 1.19 mmol), and enantiomeric excess of 97%.

Provenance & Evidence