HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentane → HCID 22731304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentane | HCID 8003 | — |
| Reactant | Trimethyl borate | HCID 8470 | — |
| Reactant | 5-Bromo-7-tert-butyl-2,3-dihydro-3,3-dimethylbenzo[b]furan | HCID 10779312 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22731304 | HCID 22731304 | — |
Reaction Steps
Following General Procedure A and using 5-bromo-3,3-dimethyl-7-t-butyl-2,3-dihydro-benzofuran (1.42 g, 7 mmol), 15 mL of anhydrous tetrahydrofuran, 1.7M solution of t-butyllithium in n-pentane (8.25 mL, 14 mmol) and trimethyl borate (1.5 mL, 14 mmol), the title compound was obtained as a foam that was used as such for the next step without purification and characterization. 5-Bromo-3,3-dimethyl-7-t-butyl-2,3-dihydro-benzofuran can be prepared as described by Janusz et al. in J. Med. Chem. 1998, 41, 1124-1137.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720423B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-e36c684c17e64b5c94c79e0b412e02b4 |
| Source note | uspto-grants-2004_04 |