Methanol → HCID 22731288, compound

Participants

Reaction Steps

Following General Procedure B and using 3,3-dimethyl-7-t-butyl-2,3-dihydro-benzofuran-5-boronic acid (Intermediate 25, 0.57 g, 2.3 mmol), 3-iodo-but-2 (Z)-ene-ol (0.4 g, 2 mmol), methanol (7.5 mL), toluene (15 mL), water (2 mL), sodium carbonate (0.5 g, 4.9 mmol) and tetrakis(triphenylphosphine)palladium(0)(60 mg), followed by flash column chromatography over silica gel (230-400 mesh) using 15% ethyl acetate in hexane as the eluent, the title compound was obtained (0.47 g, 57% over two steps).

Provenance & Evidence