HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22731297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | HCID 22731324 | HCID 22731324 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22731297 | HCID 22731297 | — |
Reaction Steps
Following General Procedure J and using 1-(5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-2,2-dimethyl-propan-1-ol. (Intermediate 31, 0.951 g, 3.05 mmol), anhydrous dichloromethane (7 mL), triethyl silane (4 mL, 12.2 mmol) and trifluoroacetic acid (2 mL, 12.2 mmol) followed by flash column chromatography using 1% ethyl acetate in hexane as the eluent, the title compound was obtained (0.7 g, 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720423B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-5fc81242ee5e4d5fb857f048ef7adb39 |
| Source note | uspto-grants-2004_04 |