Methanol → HCID 9929897, compound

Participants

Reaction Steps

Following General Procedure H and using 5-{(1S, 2S) 2-[7-(2,2-dimethyl-propyl)-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl]-2-methyl-cyclopropyl}-3-methyl-penta-2E,4E-dienoic acid ethyl ester (Compound 11, 0.132 g, 0.32 mmol), 15 mL of methanol and 5M aqueous sodium hydroxide (2 mL) followed by flash column chromatography using 25% ethyl acetate in hexane as the eluent and preparative reverse phase HPLC using 12% water in acetonitrile as the mobile phase, the title compound was obtained (0.098 g, 75%) as a white solid.

Provenance & Evidence