HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22731287, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran | HCID 5323595 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22731287 | HCID 22731287 | — |
Reaction Steps
Following General Procedure I and using aluminum chloride (1.76 g, 13.2 mmol), 20 mL of anhydrous dichloromethane, 5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran (Intermediate 2, 1.5 g, 6.61 mmol) and benzoyl chloride (1.53 mL, 13.2 mmol) followed by flash column chromatography on silica gel (230-1400 mesh) using 7% ethyl acetate in hexane as the eluent, the title compound was obtained (2.15 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720423B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-8697b62c32f44590b9b520f25a8c7f98 |
| Source note | uspto-grants-2004_04 |