HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 22731332, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | HCID 22731342 | HCID 22731342 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 22731332 | HCID 22731332 | — |
Reaction Steps
Following General Procedure J and using (5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-cyclohexyl-methanol (Intermediate 45, 0.62 g, 1.94 mmol), trifluoroacetic acid (4 mL, 52 mmol) and triethyl silane (1.5 mL, 9.4 mmol) followed by flash column chromatography using 3% ethyl acetate in hexane as the eluent, the title compound was obtained (0.58 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720423B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-c366aafabe0d4defbb46970253445372 |
| Source note | uspto-grants-2004_04 |