Dichloromethane → 5-Bromo-3,3-dimethyl-7-hexanoyl-2,3-dihydrobenzofuran

Participants

Reaction Steps

Following General Procedure I and using aluminum chloride 1.76 g, 13.2 mmol), 20 mL of anhydrous dichloromethane, hexanoyl chloride (1.76 g, 13.2 mmol) and 5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran (Intermediate 2, 1.5 g, 6.61 mmol) followed by flash column chromatography on silica gel (230-400 mesh) using 3% ethyl acetate in hexane as the eluent, the title compound was obtained as a yellow oil. It was used as such for the next step.

Provenance & Evidence