HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 5-Bromo-3,3-dimethyl-7-hexyl-2,3-dihydro-benzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 5-Bromo-3,3-dimethyl-7-hexanoyl-2,3-dihydrobenzofuran | HCID 22731298 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Bromo-3,3-dimethyl-7-hexyl-2,3-dihydro-benzofuran | HCID 22731286 | — |
Reaction Steps
Following General Procedure J and using 5-bromo-3,3-dimethyl-7-hexanoyl-2,3-dihydrobenzofuran (Intermediate 52, 0.325 g, 1.0 mmol), trifluoroacetic acid (0.31 mL, 4 mmol), triethyl silane (0.64 mL, 4 mmol) and dichloromethane (5 mL) followed by flash column chromatography using 2% ethyl acetate in hexane as the eluent, the title compound was obtained (0.20 g, 64% for 2 steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720423B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-910891ba1eae48548790226cc7216b27 |
| Source note | uspto-grants-2004_04 |