HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-(2-Bromo-phenyl)-heptan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-Bromobenzaldehyde | HCID 81129 | — |
| Reactant | HCID 178444609 | HCID 178444609 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(2-Bromo-phenyl)-heptan-1-ol | HCID 22731273 | — |
Reaction Steps
Following General Procedure K and using 2-bromo-benzaldehyde (1.5 g, 8 mmol), 15 mL of anhydrous tetrahydrofuran, and a 2M solution of n-hexyl magnesium bromide solution in ether (6 mL, 12 mmol) followed by flash column chromatography using 10% ethyl acetate in hexane, the title compound was obtained (1.86 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720423B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-393e82db8a8c4988ba6d5b36ac145e2c |
| Source note | uspto-grants-2004_04 |